mu_reference_model#

pharmpy.modeling.mu_reference_model(model)[source]#

Convert model to use mu-referencing

Mu-referencing an eta is to separately define its actual mu (mean) parameter. For example: \(CL = \theta_1 e^{\eta_1}\) with \(\eta_1\) following a zero-mean normal distribution would give \(\mu_1 = \log{\theta_1}\) and \(CL = e^{\mu_1 + \eta_1}\)

Parameters:: model (Model) – Pharmpy model object
Returns:: Model – Pharmpy model object

Example

>>> from pharmpy.modeling import load_example_model, mu_reference_model
>>> model = load_example_model("pheno")
>>> model = mu_reference_model(model)
>>> model.statements.before_odes
TVCL = POP_CL⋅WGT
TVV = POP_VC⋅WGT
      ⎧TVV⋅(COVAPGR + 1)  for APGR < 5
      ⎨
TVV = ⎩       TVV          otherwise
μ₁ = log(TVCL)
      ETA_CL + μ₁
CL = ℯ
μ₂ = log(TVV)
      ETA_VC + μ₂
VC = ℯ
V = VC
S₁ = VC