remove_peripheral_compartment#

pharmpy.modeling.remove_peripheral_compartment(model, name=None)[source]#

Remove a peripheral distribution compartment from model

If name is set, a peripheral compartment will be removed from the compartment with the specified name.

Initial estimates:

n
2	\(\mathsf{CL} = \mathsf{CL'}\), \(\mathsf{QP1} = \mathsf{CL'}\) and \(\mathsf{VP1} = \mathsf{VC'} \cdot 0.05\)
3	\(\mathsf{QP1} = (\mathsf{QP1'} + \mathsf{QP2'}) / 2\), \(\mathsf{VP1} = \mathsf{VP1'} + \mathsf{VP2'}\)

Parameters:

model (Model) – Pharmpy model
name (str) – Name of compartment to remove peripheral compartment from.

Returns:

Model – Pharmpy model object

Examples

>>> from pharmpy.modeling import *
>>> model = load_example_model("pheno")
>>> model = set_peripheral_compartments(model, 2)
>>> model = remove_peripheral_compartment(model)
>>> model.statements.ode_system
Bolus(AMT, admid=1) → CENTRAL
┌───────────┐
│PERIPHERAL1│
└───────────┘
  ↑       │
Q/V1     Q/V2
  │       ↓
┌───────────┐
│  CENTRAL  │──CL/V1→
└───────────┘