set_weibull_absorption#

pharmpy.modeling.set_weibull_absorption(model)[source]#

Set or change to Weibull type absorption

The Weibull absorption has an abosption rate varying with time (or rather time after dose). $k_a(t)=\frac{k}{\lambda }(\frac{t}{\lambda }{)}^{k-1}$

Initial parameter estimates will be set differently depending on whether the original model has MAT and/or MDT.

MAT	MDT	$k$	$\lambda$
yes	yes	1.5	$\frac{\mathsf{MAT}}{\mathrm{\Gamma }(1+\frac{1}{k})}$
yes	no	1.0	MAT
no	yes	1.0	MDT
no	no	1.5	Same as if having MAT, but use min observation time * 2

If multiple doses are fed into the affected compartment, currently only iv+oral doses (one of each) is supported.

Weibull absorption cannot be used together with lag time or transit compartments.

Assumes that absorption of one dose is complete when the next dose is given.

Parameters:

model (Model) – Model to set or change to use Weibull absorption rate

Returns:

Model – Pharmpy model object

Examples

>>> from pharmpy.modeling import *
>>> model = load_example_model("pheno")
>>> model = set_weibull_absorption(model)
>>> model.statements.ode_system
Bolus(AMT, admid=1) → DEPOT
┌─────┐      ┌───────┐
│DEPOT│──KAW→│CENTRAL│──CL/V→
└─────┘      └───────┘

See also

set_zero_order_absorption, set_first_order_absorption