set_michaelis_menten_elimination#

pharmpy.modeling.set_michaelis_menten_elimination(model)[source]#

Sets elimination to Michaelis-Menten.

Note that the parametrization is not the usual, but is instead using a CLMM parameter.

Initial estimate for CLMM is set to CL and KM is set to \(max(DV)/2\).

Parameters:: model (Model) – Pharmpy model
Returns:: Model – Pharmpy model object

Examples

>>> from pharmpy.modeling import *
>>> model = load_example_model("pheno")
>>> model = set_michaelis_menten_elimination(model)
>>> model.statements.ode_system
Bolus(AMT, admid=1) → CENTRAL
┌───────┐
│CENTRAL│──CLMM*KM/(V*(KM + A_CENTRAL(t)/V))→
└───────┘