Simeval#

Pharmpy currently creates results after a PsN simeval run.

The simeval results#

Sampled Individual OFVs#

The sampled_iofv table contains the evaluated individual OFVs for each sampled dataset.

1 2 3 4 5 6 7 8 9 10
ID
1 10.230120 6.853273 7.885525 7.860736 9.215148 15.995045 7.575351 10.488686 7.165042 8.921633
2 8.027733 12.533799 12.080061 12.568383 7.993262 9.482883 9.300884 10.824880 8.083424 10.946876
3 12.654589 17.322738 17.276361 15.376218 10.905658 11.005653 26.928279 13.916884 13.180960 19.604188
4 8.370783 13.546277 16.489785 7.898802 10.313336 10.098483 12.795252 12.638247 12.364078 9.467337
5 10.957716 14.058260 9.968860 11.773450 14.542369 9.706108 13.078494 12.136159 15.351839 9.472019
6 12.664634 9.775938 9.210594 17.600450 11.873918 10.916754 11.823449 10.151210 10.221459 9.318875
7 16.527835 8.793703 8.639544 12.104682 18.899285 10.136767 7.405150 11.551158 10.135159 9.526828
8 10.615899 10.330868 13.185132 11.354616 10.230477 11.488282 16.406903 20.796073 9.562788 13.293600
9 14.818812 14.438225 12.720261 18.884839 12.479966 14.736463 18.892761 16.486179 13.328937 15.376893
10 17.446579 9.924846 12.436720 9.367480 18.432346 19.061750 11.849137 14.121901 11.929665 11.114640
11 5.615092 11.024193 7.341680 5.054791 10.694969 5.925921 5.423537 5.512627 5.247238 5.408347
12 17.018308 16.548598 12.759167 13.864669 13.387386 13.962122 12.705806 10.842566 16.484284 10.867625
13 9.664954 6.424024 7.317393 10.280139 11.853355 8.086333 8.056381 11.638560 10.114753 7.078385
14 16.282087 13.413680 15.331177 14.631655 17.695800 13.603301 10.449888 20.622712 11.178961 15.882876
15 9.678095 7.704503 7.371773 9.758919 12.541680 14.748996 8.138213 7.361556 7.238692 9.037941
16 10.166879 10.026935 10.966413 9.814952 15.316351 11.272954 10.929655 21.422555 13.713778 12.708577
17 11.567697 10.009725 12.878300 9.715708 17.937635 9.421235 9.563473 11.266944 15.335429 12.989005
18 17.388393 22.459161 18.868224 14.383043 12.462408 14.480043 24.959843 13.212573 14.461262 14.621329
19 17.277388 12.260472 11.933191 13.676905 10.179394 8.300601 10.811596 11.003027 15.501489 12.110075
20 14.366018 10.398492 11.585174 9.956306 23.218010 11.570879 8.786560 11.380865 9.219194 21.905147
21 12.961895 18.191401 17.726349 18.445912 14.051986 19.351180 14.612812 13.546036 19.630512 22.534496
22 10.231970 8.553003 7.099846 8.876780 12.767349 6.806204 8.584818 8.682987 10.816485 8.900845
23 17.988276 15.846457 15.991350 15.924166 20.822404 14.998400 16.892200 20.802797 20.776532 17.749003
24 18.725509 21.207434 18.326447 21.115117 20.565671 23.225727 19.018880 20.662582 27.015416 21.196823
25 17.212538 28.434087 19.782192 17.806515 29.341361 26.348921 15.250063 13.488859 29.838099 14.851698
26 13.140249 11.599116 15.574493 13.296737 13.086788 15.382526 12.944073 16.743671 13.297823 15.429352
27 11.659430 7.831345 7.994987 10.574667 9.516464 9.857266 11.485191 7.880881 9.409142 12.191840
28 5.775355 5.901408 9.072216 8.874349 5.793265 6.002572 6.733704 8.630846 5.755737 5.956378
29 3.794788 3.693935 3.711150 3.676572 3.912201 4.151243 3.707700 8.483346 3.851982 3.668763
30 11.382384 8.905528 9.800871 9.954047 12.069326 11.931900 9.538437 13.793645 8.401748 8.455902
31 4.498709 6.186642 4.748099 4.731336 6.077897 4.376121 5.196475 4.928532 9.926835 6.425364
32 20.497867 16.773375 22.247095 23.504667 19.819544 17.372391 18.848184 15.366585 15.985533 17.030662
33 11.565811 8.762211 7.765259 12.455400 9.843029 8.826862 10.572217 9.551208 12.551558 8.662370
34 10.630121 11.056323 8.257409 10.502366 9.187278 8.119652 8.298009 10.552114 8.042324 8.580405
35 11.035731 10.370226 10.360000 14.305631 11.802175 12.134650 9.361844 12.040276 11.406685 9.275622
36 12.957232 10.597045 10.716192 10.544260 12.639042 13.266702 12.169391 15.515088 11.496993 14.155311
37 8.361498 9.400720 8.676934 9.022410 10.977219 8.868679 16.106708 7.751915 18.454421 7.363698
38 14.024682 13.974785 20.597599 15.424237 25.641421 15.982047 21.904024 20.952586 14.889492 15.434510
39 13.575363 16.886356 15.087082 18.098997 13.853009 14.169297 15.840067 14.073683 16.835458 18.073635
40 7.253049 5.712658 7.151935 6.963905 19.374133 8.856403 7.884553 7.879430 9.819836 8.169888
41 12.497236 17.044583 11.567520 17.351619 13.415675 12.118999 12.893425 10.178975 18.285544 12.564632
42 11.765897 14.360173 9.999275 11.255630 12.396594 9.509070 12.046265 15.264764 10.277992 9.695028
43 4.586789 4.414926 3.899880 3.408061 4.358567 3.324755 3.684344 4.572606 3.688954 3.516160
44 12.249772 13.907778 19.473731 11.297200 20.496109 12.394438 13.493584 12.244786 11.841335 13.916145
45 16.659481 8.362886 11.864820 12.606428 6.222423 15.119216 6.933397 9.416676 6.253768 7.744242
46 4.936980 4.988252 3.862927 5.693535 5.206488 4.448507 5.178177 4.069317 3.731451 5.269584
47 5.605768 6.517867 6.965455 5.764024 5.911020 6.518105 6.477206 8.716822 5.746436 5.737404
48 11.980420 21.346212 12.500103 10.133073 29.453899 10.320820 21.408266 18.125029 15.763155 11.132983
49 26.811144 16.462547 12.585654 12.027851 19.783555 11.180204 19.337790 9.583418 13.686115 24.105503
50 12.031564 23.036534 16.960296 24.402983 18.972480 23.457112 20.195385 16.363551 19.043157 19.850645
51 11.525306 10.378125 8.587323 16.032512 9.723710 15.814145 8.016286 7.892175 10.225458 9.052073
52 11.404922 10.269137 9.950516 7.788249 8.408322 10.602344 8.846592 12.242420 12.699366 10.435102
53 13.815026 9.448461 7.884049 8.777419 11.159667 10.451814 8.243399 11.512603 7.509957 7.589215
54 14.926077 21.541949 16.601504 28.416254 23.625663 14.866250 15.933824 20.175264 18.481351 17.923185
55 5.944302 4.371639 4.487277 4.418469 4.907322 4.495039 5.087071 9.194473 4.422555 4.824234
56 2.735586 2.663661 2.547459 2.675347 2.606033 2.573838 2.611250 2.550825 6.344235 2.903583
57 8.556035 14.500411 10.247584 13.271405 9.584165 10.749030 14.860290 10.875052 9.308617 10.501681
58 14.874004 19.881148 15.804622 13.876965 12.824837 12.941132 18.153441 9.432371 12.631308 13.372005
59 16.133006 10.366355 9.319025 9.885439 11.348849 17.193338 12.054769 15.323449 10.758791 16.357159

Individual OFV summary#

The iofv_summary table contain the iOFVs from the orginal model, the mean and standard deviation of the sampled iOFVs, the residual and a residual outlier flag. The residual for each sample and ID is the distance from the observed iOFV to the simulated iOFV expressed in standard deviations of the simulated values.

res=obs−mean(sim)sd(sim)

An individual is defined as an outlier if the corresponding residual is 3 or higher.

original sampled_mean sampled_stdev residual residual_q1 residual_q3 residual_outlier
ID
1 7.743042 9.219056 2.682820 -0.550173 0.035912 -0.832458 False
2 12.049484 10.184218 1.853744 1.006216 1.975298 0.136329 False
3 12.041599 15.817153 4.833045 -0.781196 -0.154061 -1.090316 False
4 12.813525 11.398238 2.645044 0.535071 1.205425 0.021748 False
5 10.092618 12.104527 2.106160 -0.955250 -0.058617 -1.766581 False
6 14.344659 11.355728 2.480441 1.205000 1.804075 1.001176 False
7 11.093249 11.372011 3.653334 -0.076303 0.579270 -0.238974 False
8 13.515891 12.726464 3.480796 0.226795 0.894556 0.071653 False
9 15.321253 15.216333 2.282456 0.045968 0.751381 -0.388881 False
10 10.998817 13.568506 3.544129 -0.725055 -0.084491 -1.584759 False
11 5.216676 6.724839 2.269729 -0.664468 -0.086120 -0.780298 False
12 12.099508 13.844053 2.234199 -0.780837 -0.277342 -1.680349 False
13 10.322169 9.051428 1.923117 0.660772 1.466385 0.043355 False
14 18.260479 14.909214 3.004430 1.115441 1.597439 0.691710 False
15 7.671231 9.358037 2.499079 -0.674971 0.086542 -0.827298 False
16 12.331370 12.633905 3.558617 -0.085015 0.554653 -0.317850 False
17 12.936751 12.068515 2.800265 0.310055 1.124015 -0.008777 False
18 19.712276 16.729628 4.167439 0.715703 1.274087 0.291308 False
19 12.019852 12.305414 2.613668 -0.109257 0.443973 -0.498512 False
20 12.056317 13.238664 5.161298 -0.229080 0.385458 -0.312807 False
21 12.248420 17.105258 3.155784 -1.539027 -0.615940 -2.178997 False
22 7.605320 9.132029 1.756164 -0.869343 -0.544161 -1.306182 False
23 19.814910 17.779158 2.268737 0.897306 1.707535 -0.116610 False
24 27.453306 21.105961 2.531367 2.507478 3.179203 2.468439 False
25 27.964192 21.235433 6.534690 1.029698 1.870557 0.007865 False
26 13.187065 14.049483 1.611648 -0.535116 0.053927 -1.384037 False
27 9.077425 9.840121 1.621227 -0.470444 0.449597 -1.344744 False
28 7.941064 6.849583 1.418397 0.769517 1.495183 -0.151930 False
29 5.074840 4.265168 1.489546 0.543569 0.924754 0.790639 False
30 9.255799 10.423379 1.792450 -0.651388 0.107140 -1.416342 False
31 5.103779 5.709601 1.655290 -0.365991 0.222470 -0.637759 False
32 19.908651 18.744590 2.726324 0.426971 1.126409 -0.153920 False
33 7.743926 10.055593 1.673502 -1.381335 -0.618133 -2.135334 False
34 8.047349 9.322600 1.222872 -1.042834 -0.180077 -2.038095 False
35 9.430602 11.209284 1.495631 -1.189252 -0.623118 -1.705065 False
36 13.780755 12.405726 1.643222 0.836788 1.746180 0.359915 False
37 8.378962 10.498420 3.745719 -0.565835 -0.016391 -0.588440 False
38 16.193803 17.882538 4.054206 -0.416539 0.288743 -1.151899 False
39 15.598975 15.649295 1.743847 -0.028856 0.860963 -0.730945 False
40 6.709391 8.906579 3.841825 -0.571912 -0.121771 -0.514178 False
41 11.219260 13.791821 2.756310 -0.933335 -0.360735 -1.784304 False
42 18.121911 11.657069 1.952413 3.311206 4.124618 2.977290 True
43 6.229621 3.945504 0.493299 4.630288 5.415407 3.707253 True
44 10.756085 14.131488 3.213636 -1.050337 -0.463633 -0.982678 False
45 10.980475 10.118333 3.749123 0.229958 1.025404 -0.384237 False
46 4.813878 4.738522 0.668408 0.112740 0.972107 -0.576792 False
47 6.235064 6.396011 0.934618 -0.172206 0.518106 -0.302778 False
48 35.392308 16.216396 6.339562 3.024801 3.793238 2.342653 True
49 12.057118 16.556378 5.796045 -0.776264 -0.019010 -1.313826 False
50 19.430617 19.431370 3.731493 -0.000202 0.527208 -0.775998 False
51 15.010968 10.724711 2.959211 1.448445 2.131466 1.274818 False
52 16.302385 10.264697 1.597597 3.779232 4.494133 3.191111 True
53 9.292477 9.639161 2.067293 -0.167700 0.637834 -0.817604 False
54 15.067793 19.249132 4.314731 -0.969084 -0.239401 -1.421290 False
55 4.359860 5.215238 1.477740 -0.578842 -0.053376 -0.461701 False
56 7.340902 3.021182 1.172446 3.684367 4.059050 3.940801 True
57 9.515114 11.245427 2.197044 -0.787564 -0.106919 -1.437023 False
58 11.970391 14.379183 2.982728 -0.807580 -0.296212 -1.207477 False
59 13.639192 12.874018 3.032032 0.252364 1.047063 -0.755739 False

Individual prediction plot#

The individual_predictions_plot show PRED, IPRED and DV vs TIME (if available) for outlying individuals.