Simeval#
Pharmpy currently creates results after a PsN simeval run.
The simeval results#
Sampled Individual OFVs#
The sampled_iofv table contains the evaluated individual OFVs for each sampled dataset.
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |
|---|---|---|---|---|---|---|---|---|---|---|
| ID | ||||||||||
| 1 | 10.488686 | 10.230120 | 6.853273 | 9.215148 | 8.921633 | 7.885525 | 7.860736 | 15.995045 | 7.575351 | 7.165042 |
| 2 | 10.824880 | 8.027733 | 12.533799 | 7.993262 | 10.946876 | 12.080061 | 12.568383 | 9.482883 | 9.300884 | 8.083424 |
| 3 | 13.916884 | 12.654589 | 17.322738 | 10.905658 | 19.604188 | 17.276361 | 15.376218 | 11.005653 | 26.928279 | 13.180960 |
| 4 | 12.638247 | 8.370783 | 13.546277 | 10.313336 | 9.467337 | 16.489785 | 7.898802 | 10.098483 | 12.795252 | 12.364078 |
| 5 | 12.136159 | 10.957716 | 14.058260 | 14.542369 | 9.472019 | 9.968860 | 11.773450 | 9.706108 | 13.078494 | 15.351839 |
| 6 | 10.151210 | 12.664634 | 9.775938 | 11.873918 | 9.318875 | 9.210594 | 17.600450 | 10.916754 | 11.823449 | 10.221459 |
| 7 | 11.551158 | 16.527835 | 8.793703 | 18.899285 | 9.526828 | 8.639544 | 12.104682 | 10.136767 | 7.405150 | 10.135159 |
| 8 | 20.796073 | 10.615899 | 10.330868 | 10.230477 | 13.293600 | 13.185132 | 11.354616 | 11.488282 | 16.406903 | 9.562788 |
| 9 | 16.486179 | 14.818812 | 14.438225 | 12.479966 | 15.376893 | 12.720261 | 18.884839 | 14.736463 | 18.892761 | 13.328937 |
| 10 | 14.121901 | 17.446579 | 9.924846 | 18.432346 | 11.114640 | 12.436720 | 9.367480 | 19.061750 | 11.849137 | 11.929665 |
| 11 | 5.512627 | 5.615092 | 11.024193 | 10.694969 | 5.408347 | 7.341680 | 5.054791 | 5.925921 | 5.423537 | 5.247238 |
| 12 | 10.842566 | 17.018308 | 16.548598 | 13.387386 | 10.867625 | 12.759167 | 13.864669 | 13.962122 | 12.705806 | 16.484284 |
| 13 | 11.638560 | 9.664954 | 6.424024 | 11.853355 | 7.078385 | 7.317393 | 10.280139 | 8.086333 | 8.056381 | 10.114753 |
| 14 | 20.622712 | 16.282087 | 13.413680 | 17.695800 | 15.882876 | 15.331177 | 14.631655 | 13.603301 | 10.449888 | 11.178961 |
| 15 | 7.361556 | 9.678095 | 7.704503 | 12.541680 | 9.037941 | 7.371773 | 9.758919 | 14.748996 | 8.138213 | 7.238692 |
| 16 | 21.422555 | 10.166879 | 10.026935 | 15.316351 | 12.708577 | 10.966413 | 9.814952 | 11.272954 | 10.929655 | 13.713778 |
| 17 | 11.266944 | 11.567697 | 10.009725 | 17.937635 | 12.989005 | 12.878300 | 9.715708 | 9.421235 | 9.563473 | 15.335429 |
| 18 | 13.212573 | 17.388393 | 22.459161 | 12.462408 | 14.621329 | 18.868224 | 14.383043 | 14.480043 | 24.959843 | 14.461262 |
| 19 | 11.003027 | 17.277388 | 12.260472 | 10.179394 | 12.110075 | 11.933191 | 13.676905 | 8.300601 | 10.811596 | 15.501489 |
| 20 | 11.380865 | 14.366018 | 10.398492 | 23.218010 | 21.905147 | 11.585174 | 9.956306 | 11.570879 | 8.786560 | 9.219194 |
| 21 | 13.546036 | 12.961895 | 18.191401 | 14.051986 | 22.534496 | 17.726349 | 18.445912 | 19.351180 | 14.612812 | 19.630512 |
| 22 | 8.682987 | 10.231970 | 8.553003 | 12.767349 | 8.900845 | 7.099846 | 8.876780 | 6.806204 | 8.584818 | 10.816485 |
| 23 | 20.802797 | 17.988276 | 15.846457 | 20.822404 | 17.749003 | 15.991350 | 15.924166 | 14.998400 | 16.892200 | 20.776532 |
| 24 | 20.662582 | 18.725509 | 21.207434 | 20.565671 | 21.196823 | 18.326447 | 21.115117 | 23.225727 | 19.018880 | 27.015416 |
| 25 | 13.488859 | 17.212538 | 28.434087 | 29.341361 | 14.851698 | 19.782192 | 17.806515 | 26.348921 | 15.250063 | 29.838099 |
| 26 | 16.743671 | 13.140249 | 11.599116 | 13.086788 | 15.429352 | 15.574493 | 13.296737 | 15.382526 | 12.944073 | 13.297823 |
| 27 | 7.880881 | 11.659430 | 7.831345 | 9.516464 | 12.191840 | 7.994987 | 10.574667 | 9.857266 | 11.485191 | 9.409142 |
| 28 | 8.630846 | 5.775355 | 5.901408 | 5.793265 | 5.956378 | 9.072216 | 8.874349 | 6.002572 | 6.733704 | 5.755737 |
| 29 | 8.483346 | 3.794788 | 3.693935 | 3.912201 | 3.668763 | 3.711150 | 3.676572 | 4.151243 | 3.707700 | 3.851982 |
| 30 | 13.793645 | 11.382384 | 8.905528 | 12.069326 | 8.455902 | 9.800871 | 9.954047 | 11.931900 | 9.538437 | 8.401748 |
| 31 | 4.928532 | 4.498709 | 6.186642 | 6.077897 | 6.425364 | 4.748099 | 4.731336 | 4.376121 | 5.196475 | 9.926835 |
| 32 | 15.366585 | 20.497867 | 16.773375 | 19.819544 | 17.030662 | 22.247095 | 23.504667 | 17.372391 | 18.848184 | 15.985533 |
| 33 | 9.551208 | 11.565811 | 8.762211 | 9.843029 | 8.662370 | 7.765259 | 12.455400 | 8.826862 | 10.572217 | 12.551558 |
| 34 | 10.552114 | 10.630121 | 11.056323 | 9.187278 | 8.580405 | 8.257409 | 10.502366 | 8.119652 | 8.298009 | 8.042324 |
| 35 | 12.040276 | 11.035731 | 10.370226 | 11.802175 | 9.275622 | 10.360000 | 14.305631 | 12.134650 | 9.361844 | 11.406685 |
| 36 | 15.515088 | 12.957232 | 10.597045 | 12.639042 | 14.155311 | 10.716192 | 10.544260 | 13.266702 | 12.169391 | 11.496993 |
| 37 | 7.751915 | 8.361498 | 9.400720 | 10.977219 | 7.363698 | 8.676934 | 9.022410 | 8.868679 | 16.106708 | 18.454421 |
| 38 | 20.952586 | 14.024682 | 13.974785 | 25.641421 | 15.434510 | 20.597599 | 15.424237 | 15.982047 | 21.904024 | 14.889492 |
| 39 | 14.073683 | 13.575363 | 16.886356 | 13.853009 | 18.073635 | 15.087082 | 18.098997 | 14.169297 | 15.840067 | 16.835458 |
| 40 | 7.879430 | 7.253049 | 5.712658 | 19.374133 | 8.169888 | 7.151935 | 6.963905 | 8.856403 | 7.884553 | 9.819836 |
| 41 | 10.178975 | 12.497236 | 17.044583 | 13.415675 | 12.564632 | 11.567520 | 17.351619 | 12.118999 | 12.893425 | 18.285544 |
| 42 | 15.264764 | 11.765897 | 14.360173 | 12.396594 | 9.695028 | 9.999275 | 11.255630 | 9.509070 | 12.046265 | 10.277992 |
| 43 | 4.572606 | 4.586789 | 4.414926 | 4.358567 | 3.516160 | 3.899880 | 3.408061 | 3.324755 | 3.684344 | 3.688954 |
| 44 | 12.244786 | 12.249772 | 13.907778 | 20.496109 | 13.916145 | 19.473731 | 11.297200 | 12.394438 | 13.493584 | 11.841335 |
| 45 | 9.416676 | 16.659481 | 8.362886 | 6.222423 | 7.744242 | 11.864820 | 12.606428 | 15.119216 | 6.933397 | 6.253768 |
| 46 | 4.069317 | 4.936980 | 4.988252 | 5.206488 | 5.269584 | 3.862927 | 5.693535 | 4.448507 | 5.178177 | 3.731451 |
| 47 | 8.716822 | 5.605768 | 6.517867 | 5.911020 | 5.737404 | 6.965455 | 5.764024 | 6.518105 | 6.477206 | 5.746436 |
| 48 | 18.125029 | 11.980420 | 21.346212 | 29.453899 | 11.132983 | 12.500103 | 10.133073 | 10.320820 | 21.408266 | 15.763155 |
| 49 | 9.583418 | 26.811144 | 16.462547 | 19.783555 | 24.105503 | 12.585654 | 12.027851 | 11.180204 | 19.337790 | 13.686115 |
| 50 | 16.363551 | 12.031564 | 23.036534 | 18.972480 | 19.850645 | 16.960296 | 24.402983 | 23.457112 | 20.195385 | 19.043157 |
| 51 | 7.892175 | 11.525306 | 10.378125 | 9.723710 | 9.052073 | 8.587323 | 16.032512 | 15.814145 | 8.016286 | 10.225458 |
| 52 | 12.242420 | 11.404922 | 10.269137 | 8.408322 | 10.435102 | 9.950516 | 7.788249 | 10.602344 | 8.846592 | 12.699366 |
| 53 | 11.512603 | 13.815026 | 9.448461 | 11.159667 | 7.589215 | 7.884049 | 8.777419 | 10.451814 | 8.243399 | 7.509957 |
| 54 | 20.175264 | 14.926077 | 21.541949 | 23.625663 | 17.923185 | 16.601504 | 28.416254 | 14.866250 | 15.933824 | 18.481351 |
| 55 | 9.194473 | 5.944302 | 4.371639 | 4.907322 | 4.824234 | 4.487277 | 4.418469 | 4.495039 | 5.087071 | 4.422555 |
| 56 | 2.550825 | 2.735586 | 2.663661 | 2.606033 | 2.903583 | 2.547459 | 2.675347 | 2.573838 | 2.611250 | 6.344235 |
| 57 | 10.875052 | 8.556035 | 14.500411 | 9.584165 | 10.501681 | 10.247584 | 13.271405 | 10.749030 | 14.860290 | 9.308617 |
| 58 | 9.432371 | 14.874004 | 19.881148 | 12.824837 | 13.372005 | 15.804622 | 13.876965 | 12.941132 | 18.153441 | 12.631308 |
| 59 | 15.323449 | 16.133006 | 10.366355 | 11.348849 | 16.357159 | 9.319025 | 9.885439 | 17.193338 | 12.054769 | 10.758791 |
Individual OFV summary#
The iofv_summary table contain the iOFVs from the orginal model, the mean and standard deviation of the sampled iOFVs, the residual and a
residual outlier flag. The residual for each sample and ID is the distance from the observed iOFV to the simulated iOFV expressed in standard deviations of the simulated values.
\[\mathrm{res} = \frac{\mathrm{obs} - \operatorname{mean}(\mathrm{sim})}{\operatorname{sd}(\mathrm{sim})}\]
An individual is defined as an outlier if the corresponding residual is 3 or higher.
| original | sampled_mean | sampled_stdev | residual | residual_q1 | residual_q3 | residual_outlier | |
|---|---|---|---|---|---|---|---|
| ID | |||||||
| 1 | 7.743042 | 9.219056 | 2.682820 | -0.550173 | 0.035912 | -0.832458 | False |
| 2 | 12.049484 | 10.184218 | 1.853744 | 1.006216 | 1.975298 | 0.136329 | False |
| 3 | 12.041599 | 15.817153 | 4.833045 | -0.781196 | -0.154061 | -1.090316 | False |
| 4 | 12.813525 | 11.398238 | 2.645044 | 0.535071 | 1.205425 | 0.021748 | False |
| 5 | 10.092618 | 12.104527 | 2.106160 | -0.955250 | -0.058617 | -1.766581 | False |
| 6 | 14.344659 | 11.355728 | 2.480441 | 1.205000 | 1.804075 | 1.001176 | False |
| 7 | 11.093249 | 11.372011 | 3.653334 | -0.076303 | 0.579270 | -0.238974 | False |
| 8 | 13.515891 | 12.726464 | 3.480796 | 0.226795 | 0.894556 | 0.071653 | False |
| 9 | 15.321253 | 15.216333 | 2.282456 | 0.045968 | 0.751381 | -0.388881 | False |
| 10 | 10.998817 | 13.568506 | 3.544129 | -0.725055 | -0.084491 | -1.584759 | False |
| 11 | 5.216676 | 6.724839 | 2.269729 | -0.664468 | -0.086120 | -0.780298 | False |
| 12 | 12.099508 | 13.844053 | 2.234199 | -0.780837 | -0.277342 | -1.680349 | False |
| 13 | 10.322169 | 9.051428 | 1.923117 | 0.660772 | 1.466385 | 0.043355 | False |
| 14 | 18.260479 | 14.909214 | 3.004430 | 1.115441 | 1.597439 | 0.691710 | False |
| 15 | 7.671231 | 9.358037 | 2.499079 | -0.674971 | 0.086542 | -0.827298 | False |
| 16 | 12.331370 | 12.633905 | 3.558617 | -0.085015 | 0.554653 | -0.317850 | False |
| 17 | 12.936751 | 12.068515 | 2.800265 | 0.310055 | 1.124015 | -0.008777 | False |
| 18 | 19.712276 | 16.729628 | 4.167439 | 0.715703 | 1.274087 | 0.291308 | False |
| 19 | 12.019852 | 12.305414 | 2.613668 | -0.109257 | 0.443973 | -0.498512 | False |
| 20 | 12.056317 | 13.238664 | 5.161298 | -0.229080 | 0.385458 | -0.312807 | False |
| 21 | 12.248420 | 17.105258 | 3.155784 | -1.539027 | -0.615940 | -2.178997 | False |
| 22 | 7.605320 | 9.132029 | 1.756164 | -0.869343 | -0.544161 | -1.306182 | False |
| 23 | 19.814910 | 17.779158 | 2.268737 | 0.897306 | 1.707535 | -0.116610 | False |
| 24 | 27.453306 | 21.105961 | 2.531367 | 2.507478 | 3.179203 | 2.468439 | False |
| 25 | 27.964192 | 21.235433 | 6.534690 | 1.029698 | 1.870557 | 0.007865 | False |
| 26 | 13.187065 | 14.049483 | 1.611648 | -0.535116 | 0.053927 | -1.384037 | False |
| 27 | 9.077425 | 9.840121 | 1.621227 | -0.470444 | 0.449597 | -1.344744 | False |
| 28 | 7.941064 | 6.849583 | 1.418397 | 0.769517 | 1.495183 | -0.151930 | False |
| 29 | 5.074840 | 4.265168 | 1.489546 | 0.543569 | 0.924754 | 0.790639 | False |
| 30 | 9.255799 | 10.423379 | 1.792450 | -0.651388 | 0.107140 | -1.416342 | False |
| 31 | 5.103779 | 5.709601 | 1.655290 | -0.365991 | 0.222470 | -0.637759 | False |
| 32 | 19.908651 | 18.744590 | 2.726324 | 0.426971 | 1.126409 | -0.153920 | False |
| 33 | 7.743926 | 10.055593 | 1.673502 | -1.381335 | -0.618133 | -2.135334 | False |
| 34 | 8.047349 | 9.322600 | 1.222872 | -1.042834 | -0.180077 | -2.038095 | False |
| 35 | 9.430602 | 11.209284 | 1.495631 | -1.189252 | -0.623118 | -1.705065 | False |
| 36 | 13.780755 | 12.405726 | 1.643222 | 0.836788 | 1.746180 | 0.359915 | False |
| 37 | 8.378962 | 10.498420 | 3.745719 | -0.565835 | -0.016391 | -0.588440 | False |
| 38 | 16.193803 | 17.882538 | 4.054206 | -0.416539 | 0.288743 | -1.151899 | False |
| 39 | 15.598975 | 15.649295 | 1.743847 | -0.028856 | 0.860963 | -0.730945 | False |
| 40 | 6.709391 | 8.906579 | 3.841825 | -0.571912 | -0.121771 | -0.514178 | False |
| 41 | 11.219260 | 13.791821 | 2.756310 | -0.933335 | -0.360735 | -1.784304 | False |
| 42 | 18.121911 | 11.657069 | 1.952413 | 3.311206 | 4.124618 | 2.977290 | True |
| 43 | 6.229621 | 3.945504 | 0.493299 | 4.630288 | 5.415407 | 3.707253 | True |
| 44 | 10.756085 | 14.131488 | 3.213636 | -1.050337 | -0.463633 | -0.982678 | False |
| 45 | 10.980475 | 10.118333 | 3.749123 | 0.229958 | 1.025404 | -0.384237 | False |
| 46 | 4.813878 | 4.738522 | 0.668408 | 0.112740 | 0.972107 | -0.576792 | False |
| 47 | 6.235064 | 6.396011 | 0.934618 | -0.172206 | 0.518106 | -0.302778 | False |
| 48 | 35.392308 | 16.216396 | 6.339562 | 3.024801 | 3.793238 | 2.342653 | True |
| 49 | 12.057118 | 16.556378 | 5.796045 | -0.776264 | -0.019010 | -1.313826 | False |
| 50 | 19.430617 | 19.431370 | 3.731493 | -0.000202 | 0.527208 | -0.775998 | False |
| 51 | 15.010968 | 10.724711 | 2.959211 | 1.448445 | 2.131466 | 1.274818 | False |
| 52 | 16.302385 | 10.264697 | 1.597597 | 3.779232 | 4.494133 | 3.191111 | True |
| 53 | 9.292477 | 9.639161 | 2.067293 | -0.167700 | 0.637834 | -0.817604 | False |
| 54 | 15.067793 | 19.249132 | 4.314731 | -0.969084 | -0.239401 | -1.421290 | False |
| 55 | 4.359860 | 5.215238 | 1.477740 | -0.578842 | -0.053376 | -0.461701 | False |
| 56 | 7.340902 | 3.021182 | 1.172446 | 3.684367 | 4.059050 | 3.940801 | True |
| 57 | 9.515114 | 11.245427 | 2.197044 | -0.787564 | -0.106919 | -1.437023 | False |
| 58 | 11.970391 | 14.379183 | 2.982728 | -0.807580 | -0.296212 | -1.207477 | False |
| 59 | 13.639192 | 12.874018 | 3.032032 | 0.252364 | 1.047063 | -0.755739 | False |
Individual prediction plot#
The individual_predictions_plot show PRED, IPRED and DV vs TIME (if available) for outlying individuals.