Simeval#

Pharmpy currently creates results after a PsN simeval run.

The simeval results#

Sampled Individual OFVs#

The sampled_iofv table contains the evaluated individual OFVs for each sampled dataset.

1 2 3 4 5 6 7 8 9 10
ID
1 8.921633 7.885525 7.860736 10.488686 10.230120 7.165042 6.853273 9.215148 15.995045 7.575351
2 10.946876 12.080061 12.568383 10.824880 8.027733 8.083424 12.533799 7.993262 9.482883 9.300884
3 19.604188 17.276361 15.376218 13.916884 12.654589 13.180960 17.322738 10.905658 11.005653 26.928279
4 9.467337 16.489785 7.898802 12.638247 8.370783 12.364078 13.546277 10.313336 10.098483 12.795252
5 9.472019 9.968860 11.773450 12.136159 10.957716 15.351839 14.058260 14.542369 9.706108 13.078494
6 9.318875 9.210594 17.600450 10.151210 12.664634 10.221459 9.775938 11.873918 10.916754 11.823449
7 9.526828 8.639544 12.104682 11.551158 16.527835 10.135159 8.793703 18.899285 10.136767 7.405150
8 13.293600 13.185132 11.354616 20.796073 10.615899 9.562788 10.330868 10.230477 11.488282 16.406903
9 15.376893 12.720261 18.884839 16.486179 14.818812 13.328937 14.438225 12.479966 14.736463 18.892761
10 11.114640 12.436720 9.367480 14.121901 17.446579 11.929665 9.924846 18.432346 19.061750 11.849137
11 5.408347 7.341680 5.054791 5.512627 5.615092 5.247238 11.024193 10.694969 5.925921 5.423537
12 10.867625 12.759167 13.864669 10.842566 17.018308 16.484284 16.548598 13.387386 13.962122 12.705806
13 7.078385 7.317393 10.280139 11.638560 9.664954 10.114753 6.424024 11.853355 8.086333 8.056381
14 15.882876 15.331177 14.631655 20.622712 16.282087 11.178961 13.413680 17.695800 13.603301 10.449888
15 9.037941 7.371773 9.758919 7.361556 9.678095 7.238692 7.704503 12.541680 14.748996 8.138213
16 12.708577 10.966413 9.814952 21.422555 10.166879 13.713778 10.026935 15.316351 11.272954 10.929655
17 12.989005 12.878300 9.715708 11.266944 11.567697 15.335429 10.009725 17.937635 9.421235 9.563473
18 14.621329 18.868224 14.383043 13.212573 17.388393 14.461262 22.459161 12.462408 14.480043 24.959843
19 12.110075 11.933191 13.676905 11.003027 17.277388 15.501489 12.260472 10.179394 8.300601 10.811596
20 21.905147 11.585174 9.956306 11.380865 14.366018 9.219194 10.398492 23.218010 11.570879 8.786560
21 22.534496 17.726349 18.445912 13.546036 12.961895 19.630512 18.191401 14.051986 19.351180 14.612812
22 8.900845 7.099846 8.876780 8.682987 10.231970 10.816485 8.553003 12.767349 6.806204 8.584818
23 17.749003 15.991350 15.924166 20.802797 17.988276 20.776532 15.846457 20.822404 14.998400 16.892200
24 21.196823 18.326447 21.115117 20.662582 18.725509 27.015416 21.207434 20.565671 23.225727 19.018880
25 14.851698 19.782192 17.806515 13.488859 17.212538 29.838099 28.434087 29.341361 26.348921 15.250063
26 15.429352 15.574493 13.296737 16.743671 13.140249 13.297823 11.599116 13.086788 15.382526 12.944073
27 12.191840 7.994987 10.574667 7.880881 11.659430 9.409142 7.831345 9.516464 9.857266 11.485191
28 5.956378 9.072216 8.874349 8.630846 5.775355 5.755737 5.901408 5.793265 6.002572 6.733704
29 3.668763 3.711150 3.676572 8.483346 3.794788 3.851982 3.693935 3.912201 4.151243 3.707700
30 8.455902 9.800871 9.954047 13.793645 11.382384 8.401748 8.905528 12.069326 11.931900 9.538437
31 6.425364 4.748099 4.731336 4.928532 4.498709 9.926835 6.186642 6.077897 4.376121 5.196475
32 17.030662 22.247095 23.504667 15.366585 20.497867 15.985533 16.773375 19.819544 17.372391 18.848184
33 8.662370 7.765259 12.455400 9.551208 11.565811 12.551558 8.762211 9.843029 8.826862 10.572217
34 8.580405 8.257409 10.502366 10.552114 10.630121 8.042324 11.056323 9.187278 8.119652 8.298009
35 9.275622 10.360000 14.305631 12.040276 11.035731 11.406685 10.370226 11.802175 12.134650 9.361844
36 14.155311 10.716192 10.544260 15.515088 12.957232 11.496993 10.597045 12.639042 13.266702 12.169391
37 7.363698 8.676934 9.022410 7.751915 8.361498 18.454421 9.400720 10.977219 8.868679 16.106708
38 15.434510 20.597599 15.424237 20.952586 14.024682 14.889492 13.974785 25.641421 15.982047 21.904024
39 18.073635 15.087082 18.098997 14.073683 13.575363 16.835458 16.886356 13.853009 14.169297 15.840067
40 8.169888 7.151935 6.963905 7.879430 7.253049 9.819836 5.712658 19.374133 8.856403 7.884553
41 12.564632 11.567520 17.351619 10.178975 12.497236 18.285544 17.044583 13.415675 12.118999 12.893425
42 9.695028 9.999275 11.255630 15.264764 11.765897 10.277992 14.360173 12.396594 9.509070 12.046265
43 3.516160 3.899880 3.408061 4.572606 4.586789 3.688954 4.414926 4.358567 3.324755 3.684344
44 13.916145 19.473731 11.297200 12.244786 12.249772 11.841335 13.907778 20.496109 12.394438 13.493584
45 7.744242 11.864820 12.606428 9.416676 16.659481 6.253768 8.362886 6.222423 15.119216 6.933397
46 5.269584 3.862927 5.693535 4.069317 4.936980 3.731451 4.988252 5.206488 4.448507 5.178177
47 5.737404 6.965455 5.764024 8.716822 5.605768 5.746436 6.517867 5.911020 6.518105 6.477206
48 11.132983 12.500103 10.133073 18.125029 11.980420 15.763155 21.346212 29.453899 10.320820 21.408266
49 24.105503 12.585654 12.027851 9.583418 26.811144 13.686115 16.462547 19.783555 11.180204 19.337790
50 19.850645 16.960296 24.402983 16.363551 12.031564 19.043157 23.036534 18.972480 23.457112 20.195385
51 9.052073 8.587323 16.032512 7.892175 11.525306 10.225458 10.378125 9.723710 15.814145 8.016286
52 10.435102 9.950516 7.788249 12.242420 11.404922 12.699366 10.269137 8.408322 10.602344 8.846592
53 7.589215 7.884049 8.777419 11.512603 13.815026 7.509957 9.448461 11.159667 10.451814 8.243399
54 17.923185 16.601504 28.416254 20.175264 14.926077 18.481351 21.541949 23.625663 14.866250 15.933824
55 4.824234 4.487277 4.418469 9.194473 5.944302 4.422555 4.371639 4.907322 4.495039 5.087071
56 2.903583 2.547459 2.675347 2.550825 2.735586 6.344235 2.663661 2.606033 2.573838 2.611250
57 10.501681 10.247584 13.271405 10.875052 8.556035 9.308617 14.500411 9.584165 10.749030 14.860290
58 13.372005 15.804622 13.876965 9.432371 14.874004 12.631308 19.881148 12.824837 12.941132 18.153441
59 16.357159 9.319025 9.885439 15.323449 16.133006 10.758791 10.366355 11.348849 17.193338 12.054769

Individual OFV summary#

The iofv_summary table contain the iOFVs from the orginal model, the mean and standard deviation of the sampled iOFVs, the residual and a residual outlier flag. The residual for each sample and ID is the distance from the observed iOFV to the simulated iOFV expressed in standard deviations of the simulated values.

res=obs−mean(sim)sd(sim)

An individual is defined as an outlier if the corresponding residual is 3 or higher.

original sampled_mean sampled_stdev residual residual_q1 residual_q3 residual_outlier
ID
1 7.743042 9.219056 2.682820 -0.550173 0.035912 -0.832458 False
2 12.049484 10.184218 1.853744 1.006216 1.975298 0.136329 False
3 12.041599 15.817153 4.833045 -0.781196 -0.154061 -1.090316 False
4 12.813525 11.398238 2.645044 0.535071 1.205425 0.021748 False
5 10.092618 12.104527 2.106160 -0.955250 -0.058617 -1.766581 False
6 14.344659 11.355728 2.480441 1.205000 1.804075 1.001176 False
7 11.093249 11.372011 3.653334 -0.076303 0.579270 -0.238974 False
8 13.515891 12.726464 3.480796 0.226795 0.894556 0.071653 False
9 15.321253 15.216333 2.282456 0.045968 0.751381 -0.388881 False
10 10.998817 13.568506 3.544129 -0.725055 -0.084491 -1.584759 False
11 5.216676 6.724839 2.269729 -0.664468 -0.086120 -0.780298 False
12 12.099508 13.844053 2.234199 -0.780837 -0.277342 -1.680349 False
13 10.322169 9.051428 1.923117 0.660772 1.466385 0.043355 False
14 18.260479 14.909214 3.004430 1.115441 1.597439 0.691710 False
15 7.671231 9.358037 2.499079 -0.674971 0.086542 -0.827298 False
16 12.331370 12.633905 3.558617 -0.085015 0.554653 -0.317850 False
17 12.936751 12.068515 2.800265 0.310055 1.124015 -0.008777 False
18 19.712276 16.729628 4.167439 0.715703 1.274087 0.291308 False
19 12.019852 12.305414 2.613668 -0.109257 0.443973 -0.498512 False
20 12.056317 13.238664 5.161298 -0.229080 0.385458 -0.312807 False
21 12.248420 17.105258 3.155784 -1.539027 -0.615940 -2.178997 False
22 7.605320 9.132029 1.756164 -0.869343 -0.544161 -1.306182 False
23 19.814910 17.779158 2.268737 0.897306 1.707535 -0.116610 False
24 27.453306 21.105961 2.531367 2.507478 3.179203 2.468439 False
25 27.964192 21.235433 6.534690 1.029698 1.870557 0.007865 False
26 13.187065 14.049483 1.611648 -0.535116 0.053927 -1.384037 False
27 9.077425 9.840121 1.621227 -0.470444 0.449597 -1.344744 False
28 7.941064 6.849583 1.418397 0.769517 1.495183 -0.151930 False
29 5.074840 4.265168 1.489546 0.543569 0.924754 0.790639 False
30 9.255799 10.423379 1.792450 -0.651388 0.107140 -1.416342 False
31 5.103779 5.709601 1.655290 -0.365991 0.222470 -0.637759 False
32 19.908651 18.744590 2.726324 0.426971 1.126409 -0.153920 False
33 7.743926 10.055593 1.673502 -1.381335 -0.618133 -2.135334 False
34 8.047349 9.322600 1.222872 -1.042834 -0.180077 -2.038095 False
35 9.430602 11.209284 1.495631 -1.189252 -0.623118 -1.705065 False
36 13.780755 12.405726 1.643222 0.836788 1.746180 0.359915 False
37 8.378962 10.498420 3.745719 -0.565835 -0.016391 -0.588440 False
38 16.193803 17.882538 4.054206 -0.416539 0.288743 -1.151899 False
39 15.598975 15.649295 1.743847 -0.028856 0.860963 -0.730945 False
40 6.709391 8.906579 3.841825 -0.571912 -0.121771 -0.514178 False
41 11.219260 13.791821 2.756310 -0.933335 -0.360735 -1.784304 False
42 18.121911 11.657069 1.952413 3.311206 4.124618 2.977290 True
43 6.229621 3.945504 0.493299 4.630288 5.415407 3.707253 True
44 10.756085 14.131488 3.213636 -1.050337 -0.463633 -0.982678 False
45 10.980475 10.118333 3.749123 0.229958 1.025404 -0.384237 False
46 4.813878 4.738522 0.668408 0.112740 0.972107 -0.576792 False
47 6.235064 6.396011 0.934618 -0.172206 0.518106 -0.302778 False
48 35.392308 16.216396 6.339562 3.024801 3.793238 2.342653 True
49 12.057118 16.556378 5.796045 -0.776264 -0.019010 -1.313826 False
50 19.430617 19.431370 3.731493 -0.000202 0.527208 -0.775998 False
51 15.010968 10.724711 2.959211 1.448445 2.131466 1.274818 False
52 16.302385 10.264697 1.597597 3.779232 4.494133 3.191111 True
53 9.292477 9.639161 2.067293 -0.167700 0.637834 -0.817604 False
54 15.067793 19.249132 4.314731 -0.969084 -0.239401 -1.421290 False
55 4.359860 5.215238 1.477740 -0.578842 -0.053376 -0.461701 False
56 7.340902 3.021182 1.172446 3.684367 4.059050 3.940801 True
57 9.515114 11.245427 2.197044 -0.787564 -0.106919 -1.437023 False
58 11.970391 14.379183 2.982728 -0.807580 -0.296212 -1.207477 False
59 13.639192 12.874018 3.032032 0.252364 1.047063 -0.755739 False

Individual prediction plot#

The individual_predictions_plot show PRED, IPRED and DV vs TIME (if available) for outlying individuals.