Simeval#

Pharmpy currently creates results after a PsN simeval run.

The simeval results#

Sampled Individual OFVs#

The sampled_iofv table contains the evaluated individual OFVs for each sampled dataset.

1 2 3 4 5 6 7 8 9 10
ID
1 15.995045 7.575351 7.885525 7.860736 7.165042 6.853273 10.488686 9.215148 8.921633 10.230120
2 9.482883 9.300884 12.080061 12.568383 8.083424 12.533799 10.824880 7.993262 10.946876 8.027733
3 11.005653 26.928279 17.276361 15.376218 13.180960 17.322738 13.916884 10.905658 19.604188 12.654589
4 10.098483 12.795252 16.489785 7.898802 12.364078 13.546277 12.638247 10.313336 9.467337 8.370783
5 9.706108 13.078494 9.968860 11.773450 15.351839 14.058260 12.136159 14.542369 9.472019 10.957716
6 10.916754 11.823449 9.210594 17.600450 10.221459 9.775938 10.151210 11.873918 9.318875 12.664634
7 10.136767 7.405150 8.639544 12.104682 10.135159 8.793703 11.551158 18.899285 9.526828 16.527835
8 11.488282 16.406903 13.185132 11.354616 9.562788 10.330868 20.796073 10.230477 13.293600 10.615899
9 14.736463 18.892761 12.720261 18.884839 13.328937 14.438225 16.486179 12.479966 15.376893 14.818812
10 19.061750 11.849137 12.436720 9.367480 11.929665 9.924846 14.121901 18.432346 11.114640 17.446579
11 5.925921 5.423537 7.341680 5.054791 5.247238 11.024193 5.512627 10.694969 5.408347 5.615092
12 13.962122 12.705806 12.759167 13.864669 16.484284 16.548598 10.842566 13.387386 10.867625 17.018308
13 8.086333 8.056381 7.317393 10.280139 10.114753 6.424024 11.638560 11.853355 7.078385 9.664954
14 13.603301 10.449888 15.331177 14.631655 11.178961 13.413680 20.622712 17.695800 15.882876 16.282087
15 14.748996 8.138213 7.371773 9.758919 7.238692 7.704503 7.361556 12.541680 9.037941 9.678095
16 11.272954 10.929655 10.966413 9.814952 13.713778 10.026935 21.422555 15.316351 12.708577 10.166879
17 9.421235 9.563473 12.878300 9.715708 15.335429 10.009725 11.266944 17.937635 12.989005 11.567697
18 14.480043 24.959843 18.868224 14.383043 14.461262 22.459161 13.212573 12.462408 14.621329 17.388393
19 8.300601 10.811596 11.933191 13.676905 15.501489 12.260472 11.003027 10.179394 12.110075 17.277388
20 11.570879 8.786560 11.585174 9.956306 9.219194 10.398492 11.380865 23.218010 21.905147 14.366018
21 19.351180 14.612812 17.726349 18.445912 19.630512 18.191401 13.546036 14.051986 22.534496 12.961895
22 6.806204 8.584818 7.099846 8.876780 10.816485 8.553003 8.682987 12.767349 8.900845 10.231970
23 14.998400 16.892200 15.991350 15.924166 20.776532 15.846457 20.802797 20.822404 17.749003 17.988276
24 23.225727 19.018880 18.326447 21.115117 27.015416 21.207434 20.662582 20.565671 21.196823 18.725509
25 26.348921 15.250063 19.782192 17.806515 29.838099 28.434087 13.488859 29.341361 14.851698 17.212538
26 15.382526 12.944073 15.574493 13.296737 13.297823 11.599116 16.743671 13.086788 15.429352 13.140249
27 9.857266 11.485191 7.994987 10.574667 9.409142 7.831345 7.880881 9.516464 12.191840 11.659430
28 6.002572 6.733704 9.072216 8.874349 5.755737 5.901408 8.630846 5.793265 5.956378 5.775355
29 4.151243 3.707700 3.711150 3.676572 3.851982 3.693935 8.483346 3.912201 3.668763 3.794788
30 11.931900 9.538437 9.800871 9.954047 8.401748 8.905528 13.793645 12.069326 8.455902 11.382384
31 4.376121 5.196475 4.748099 4.731336 9.926835 6.186642 4.928532 6.077897 6.425364 4.498709
32 17.372391 18.848184 22.247095 23.504667 15.985533 16.773375 15.366585 19.819544 17.030662 20.497867
33 8.826862 10.572217 7.765259 12.455400 12.551558 8.762211 9.551208 9.843029 8.662370 11.565811
34 8.119652 8.298009 8.257409 10.502366 8.042324 11.056323 10.552114 9.187278 8.580405 10.630121
35 12.134650 9.361844 10.360000 14.305631 11.406685 10.370226 12.040276 11.802175 9.275622 11.035731
36 13.266702 12.169391 10.716192 10.544260 11.496993 10.597045 15.515088 12.639042 14.155311 12.957232
37 8.868679 16.106708 8.676934 9.022410 18.454421 9.400720 7.751915 10.977219 7.363698 8.361498
38 15.982047 21.904024 20.597599 15.424237 14.889492 13.974785 20.952586 25.641421 15.434510 14.024682
39 14.169297 15.840067 15.087082 18.098997 16.835458 16.886356 14.073683 13.853009 18.073635 13.575363
40 8.856403 7.884553 7.151935 6.963905 9.819836 5.712658 7.879430 19.374133 8.169888 7.253049
41 12.118999 12.893425 11.567520 17.351619 18.285544 17.044583 10.178975 13.415675 12.564632 12.497236
42 9.509070 12.046265 9.999275 11.255630 10.277992 14.360173 15.264764 12.396594 9.695028 11.765897
43 3.324755 3.684344 3.899880 3.408061 3.688954 4.414926 4.572606 4.358567 3.516160 4.586789
44 12.394438 13.493584 19.473731 11.297200 11.841335 13.907778 12.244786 20.496109 13.916145 12.249772
45 15.119216 6.933397 11.864820 12.606428 6.253768 8.362886 9.416676 6.222423 7.744242 16.659481
46 4.448507 5.178177 3.862927 5.693535 3.731451 4.988252 4.069317 5.206488 5.269584 4.936980
47 6.518105 6.477206 6.965455 5.764024 5.746436 6.517867 8.716822 5.911020 5.737404 5.605768
48 10.320820 21.408266 12.500103 10.133073 15.763155 21.346212 18.125029 29.453899 11.132983 11.980420
49 11.180204 19.337790 12.585654 12.027851 13.686115 16.462547 9.583418 19.783555 24.105503 26.811144
50 23.457112 20.195385 16.960296 24.402983 19.043157 23.036534 16.363551 18.972480 19.850645 12.031564
51 15.814145 8.016286 8.587323 16.032512 10.225458 10.378125 7.892175 9.723710 9.052073 11.525306
52 10.602344 8.846592 9.950516 7.788249 12.699366 10.269137 12.242420 8.408322 10.435102 11.404922
53 10.451814 8.243399 7.884049 8.777419 7.509957 9.448461 11.512603 11.159667 7.589215 13.815026
54 14.866250 15.933824 16.601504 28.416254 18.481351 21.541949 20.175264 23.625663 17.923185 14.926077
55 4.495039 5.087071 4.487277 4.418469 4.422555 4.371639 9.194473 4.907322 4.824234 5.944302
56 2.573838 2.611250 2.547459 2.675347 6.344235 2.663661 2.550825 2.606033 2.903583 2.735586
57 10.749030 14.860290 10.247584 13.271405 9.308617 14.500411 10.875052 9.584165 10.501681 8.556035
58 12.941132 18.153441 15.804622 13.876965 12.631308 19.881148 9.432371 12.824837 13.372005 14.874004
59 17.193338 12.054769 9.319025 9.885439 10.758791 10.366355 15.323449 11.348849 16.357159 16.133006

Individual OFV summary#

The iofv_summary table contain the iOFVs from the orginal model, the mean and standard deviation of the sampled iOFVs, the residual and a residual outlier flag. The residual for each sample and ID is the distance from the observed iOFV to the simulated iOFV expressed in standard deviations of the simulated values.

res=obs−mean(sim)sd(sim)

An individual is defined as an outlier if the corresponding residual is 3 or higher.

original sampled_mean sampled_stdev residual residual_q1 residual_q3 residual_outlier
ID
1 7.743042 9.219056 2.682820 -0.550173 0.035912 -0.832458 False
2 12.049484 10.184218 1.853744 1.006216 1.975298 0.136329 False
3 12.041599 15.817153 4.833045 -0.781196 -0.154061 -1.090316 False
4 12.813525 11.398238 2.645044 0.535071 1.205425 0.021748 False
5 10.092618 12.104527 2.106160 -0.955250 -0.058617 -1.766581 False
6 14.344659 11.355728 2.480441 1.205000 1.804075 1.001176 False
7 11.093249 11.372011 3.653334 -0.076303 0.579270 -0.238974 False
8 13.515891 12.726464 3.480796 0.226795 0.894556 0.071653 False
9 15.321253 15.216333 2.282456 0.045968 0.751381 -0.388881 False
10 10.998817 13.568506 3.544129 -0.725055 -0.084491 -1.584759 False
11 5.216676 6.724839 2.269729 -0.664468 -0.086120 -0.780298 False
12 12.099508 13.844053 2.234199 -0.780837 -0.277342 -1.680349 False
13 10.322169 9.051428 1.923117 0.660772 1.466385 0.043355 False
14 18.260479 14.909214 3.004430 1.115441 1.597439 0.691710 False
15 7.671231 9.358037 2.499079 -0.674971 0.086542 -0.827298 False
16 12.331370 12.633905 3.558617 -0.085015 0.554653 -0.317850 False
17 12.936751 12.068515 2.800265 0.310055 1.124015 -0.008777 False
18 19.712276 16.729628 4.167439 0.715703 1.274087 0.291308 False
19 12.019852 12.305414 2.613668 -0.109257 0.443973 -0.498512 False
20 12.056317 13.238664 5.161298 -0.229080 0.385458 -0.312807 False
21 12.248420 17.105258 3.155784 -1.539027 -0.615940 -2.178997 False
22 7.605320 9.132029 1.756164 -0.869343 -0.544161 -1.306182 False
23 19.814910 17.779158 2.268737 0.897306 1.707535 -0.116610 False
24 27.453306 21.105961 2.531367 2.507478 3.179203 2.468439 False
25 27.964192 21.235433 6.534690 1.029698 1.870557 0.007865 False
26 13.187065 14.049483 1.611648 -0.535116 0.053927 -1.384037 False
27 9.077425 9.840121 1.621227 -0.470444 0.449597 -1.344744 False
28 7.941064 6.849583 1.418397 0.769517 1.495183 -0.151930 False
29 5.074840 4.265168 1.489546 0.543569 0.924754 0.790639 False
30 9.255799 10.423379 1.792450 -0.651388 0.107140 -1.416342 False
31 5.103779 5.709601 1.655290 -0.365991 0.222470 -0.637759 False
32 19.908651 18.744590 2.726324 0.426971 1.126409 -0.153920 False
33 7.743926 10.055593 1.673502 -1.381335 -0.618133 -2.135334 False
34 8.047349 9.322600 1.222872 -1.042834 -0.180077 -2.038095 False
35 9.430602 11.209284 1.495631 -1.189252 -0.623118 -1.705065 False
36 13.780755 12.405726 1.643222 0.836788 1.746180 0.359915 False
37 8.378962 10.498420 3.745719 -0.565835 -0.016391 -0.588440 False
38 16.193803 17.882538 4.054206 -0.416539 0.288743 -1.151899 False
39 15.598975 15.649295 1.743847 -0.028856 0.860963 -0.730945 False
40 6.709391 8.906579 3.841825 -0.571912 -0.121771 -0.514178 False
41 11.219260 13.791821 2.756310 -0.933335 -0.360735 -1.784304 False
42 18.121911 11.657069 1.952413 3.311206 4.124618 2.977290 True
43 6.229621 3.945504 0.493299 4.630288 5.415407 3.707253 True
44 10.756085 14.131488 3.213636 -1.050337 -0.463633 -0.982678 False
45 10.980475 10.118333 3.749123 0.229958 1.025404 -0.384237 False
46 4.813878 4.738522 0.668408 0.112740 0.972107 -0.576792 False
47 6.235064 6.396011 0.934618 -0.172206 0.518106 -0.302778 False
48 35.392308 16.216396 6.339562 3.024801 3.793238 2.342653 True
49 12.057118 16.556378 5.796045 -0.776264 -0.019010 -1.313826 False
50 19.430617 19.431370 3.731493 -0.000202 0.527208 -0.775998 False
51 15.010968 10.724711 2.959211 1.448445 2.131466 1.274818 False
52 16.302385 10.264697 1.597597 3.779232 4.494133 3.191111 True
53 9.292477 9.639161 2.067293 -0.167700 0.637834 -0.817604 False
54 15.067793 19.249132 4.314731 -0.969084 -0.239401 -1.421290 False
55 4.359860 5.215238 1.477740 -0.578842 -0.053376 -0.461701 False
56 7.340902 3.021182 1.172446 3.684367 4.059050 3.940801 True
57 9.515114 11.245427 2.197044 -0.787564 -0.106919 -1.437023 False
58 11.970391 14.379183 2.982728 -0.807580 -0.296212 -1.207477 False
59 13.639192 12.874018 3.032032 0.252364 1.047063 -0.755739 False

Individual prediction plot#

The individual_predictions_plot show PRED, IPRED and DV vs TIME (if available) for outlying individuals.